Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States
| Autor: | Jason Thomas, Kristin Kostka, Carlos Areia, Paula Casajust, Andrew E. Williams, Mengchun Gong, Anna Ostropolets, George Hripcsak, Scott L. DuVall, Marc A. Suchard, Peter R. Rijnbeek, Jennifer C E Lane, Martina Recalde, Daniel R. Morales, Jose D. Posada, Adam B. Wilcox, Maria Tereza Fernandes Abrahão, Osaid Alser, Clair Blacketer, Fredrik Nyberg, Ying Zhang, Anthony G. Sena, Christian G. Reich, Sergio Fernandez-Bertolin, Patrick B. Ryan, Lin Zhang, Jitendra Jonnagaddala, Thomas Falconer, Seng Chan You, David Vizcaya, Frank J. DeFalco, Vignesh Subbian, Michael E. Matheny, Karthik Natarajan, Waheed-Ul-Rahman Ahmed, Asieh Golozar, Thamir M. Alshammari, Hamed Abedtash, Heba Alghoul, Lana Yh Lai, Matthew E. Spotnitz, Elena Roel, Alan Andryc, Nigam H. Shah, Vojtech Huser, Kristine E. Lynch, Karishma Shah, Yin Guan, Stephen Fortin, Talita Duarte-Salles, Daniel Prieto-Alhambra, Lisa M. Schilling, Albert Prats-Uribe |
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| Rok vydání: | 2020 |
| Předmět: |
EHR
020205 medical informatics Coronavirus disease 2019 (COVID-19) business.industry Characterisation Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) MEDLINE COVID-19 02 engineering and technology medicine.disease Comorbidity Article 3. Good health Comorbidities 03 medical and health sciences 0302 clinical medicine Scale (social sciences) Pandemic Cohort 0202 electrical engineering electronic engineering information engineering Medicine 030212 general & internal medicine Baseline (configuration management) business Demography |
| Zdroj: | medRxiv |
| Popis: | Early identification of symptoms and comorbidities most predictive of COVID-19 is critical to identify infection, guide policies to effectively contain the pandemic, and improve health systems’ response. Here, we characterised socio-demographics and comorbidity in 3,316,107persons tested and 219,072 persons tested positive for SARS-CoV-2 since January 2020, and their key health outcomes in the month following the first positive test. Routine care data from primary care electronic health records (EHR) from Spain, hospital EHR from the United States (US), and claims data from South Korea and the US were used. The majority of study participants were women aged 18-65 years old. Positive/tested ratio varied greatly geographically (2.2:100 to 31.2:100) and over time (from 50:100 in February-April to 6.8:100 in May-June). Fever, cough and dyspnoea were the most common symptoms at presentation. Between 4%-38% required admission and 1-10.5% died within a month from their first positive test. Observed disparity in testing practices led to variable baseline characteristics and outcomes, both nationally (US) and internationally. Our findings highlight the importance of large scale characterization of COVID-19 international cohorts to inform planning and resource allocation including testing as countries face a second wave. |
| Databáze: | OpenAIRE |
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