Dietary Fiber Supplementation and Fecal Bile Acids, Neutral Steroids and Divalent Cations in Rats
| Autor: | David Kritchevsky, Don W. Watkins, Marie M. Cassidy, Reza Khalafi, Jon A. Story, George V. Vahouny, Subramanian Satchithanandam |
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| Rok vydání: | 1987 |
| Předmět: |
Dietary Fiber
Male food.ingredient Pectin Cations Divalent medicine.drug_class Medicine (miscellaneous) Bile Acids and Salts Feces food Bile acid sequestrant medicine Animals Food science Fiber Nutrition and Dietetics Guar gum Cholestyramine Cholestanes Bile acid Chemistry Feces analysis Rats Inbred Strains Psyllium Rats Cholestanol Sterols Cholesterol Biochemistry Food Fortified medicine.drug |
| Zdroj: | The Journal of Nutrition. 117:2009-2015 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/117.12.2009 |
| Popis: | Young adult rats were fed ad libitum for 4 wk on defined diets containing either no fiber, 10% levels of insoluble fiber sources [cellulose, wheat bran, alfalfa, mixed fibers (Fibyrax)], 5% levels of soluble fiber sources [pectin, guar gum, psyllium (Metamucil)] or 2% cholestyramine (Questran), a bile acid sequestrant. Fecal samples were obtained from paired rats over a 3-d period, were analyzed for neutral and acidic steroid levels and compositions and, together with the food, were assayed for divalent cations (Ca2+, Mg2+, Fe2+ and Zn2+). Animals in all groups were in balance for divalent cations, and there appeared to be no relationship between the extent of cation balance and the type of fiber fed. All insoluble fiber diets and the guar gum and psyllium diets resulted in significantly higher daily fecal mass and, in general, resulted in significant dilution of total fecal steroids. With the insoluble fibers, there was a general dilution of fecal neutral steroids, which was not apparent with the soluble fibers or cholestyramine. In addition, except for the pectin- and mixed fiber-containing diets, there was reduced bacterial conversion of the primary bile acids to secondary bile acids or metabolites. |
| Databáze: | OpenAIRE |
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