Effect of aortic root infusion of sufentanil on ischemia-reperfusion injury in patients undergoing mitral valve replacement
| Autor: | Erwei Gu, Youmei Zuo, Xinqi Cheng, Yuanyuan Cao, Xun-qin Liu, Lei Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Cardiac output Sufentanil medicine.medical_treatment Blood Pressure Myocardial Reperfusion Injury Sodium Chloride law.invention Catheters Indwelling law Heart Rate Internal medicine Cardiopulmonary bypass Medicine Creatine Kinase MB Form Humans Prospective Studies Cardiac Output Heart Valve Prosthesis Implantation Cardiopulmonary Bypass business.industry Troponin I Mitral valve replacement Central venous pressure Stroke volume Length of Stay Middle Aged Cardiac surgery Analgesics Opioid Anesthesiology and Pain Medicine Anesthesia Aortic Valve Cardiology Mitral Valve Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiothoracic and vascular anesthesia. 28(6) |
| ISSN: | 1532-8422 |
| Popis: | This study investigated the effects of aortic root infusion of sufentanil on myocardial ischemia/reperfusion injury in patients undergoing elective mitral valve replacement (MVR) with cardiopulmonary bypass (CPB).A prospective, randomized, clinical study.A university-affiliated teaching hospital.Fifty-three adult patients undergoing elective MVR with CPB.Bolus infusions of sufentanil (0.2 μg/kg, n = 24) or normal saline (n = 29) were administered through the aortic root cardioplegia perfusion catheter 5 minutes before aortic unclamping.Plasma concentrations of CK-MB and cTnI and variables including heart rate, mean arterial pressure, central venous pressure, cardiac output, stroke volume, duration of mechanical ventilation, length of ICU stay, length of hospital stay, and 24-hour postoperative inotropic scores were recorded. Plasma concentrations of CK-MB and cTnI were significantly lower 4 and 8 hours after aortic unclamping in the sufentanil postconditioning group compared to control (p0.05). Inotropic drug use, duration of mechanical ventilation, and length of ICU and hospital stays were reduced significantly in the sufentanil postconditioning group compared to control (p0.05).The present study demonstrated that sufentanil can attenuate myocardial ischemia-reperfusion injury in patients undergoing elective MVR with CPB. |
| Databáze: | OpenAIRE |
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