Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice
| Autor: | Hong-Bo Weng, Yun-Yi Zhang, Lijun Ling, Daofeng Chen, Tao Zeng, Yuchen Feng, Hong Li |
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| Rok vydání: | 2019 |
| Předmět: |
Bupleurum
Male Colon Inflammation 02 engineering and technology Pharmacology Gut flora Polysaccharide Kidney digestive system Biochemistry Diabetic nephropathy 03 medical and health sciences Mice Structural Biology Polysaccharides medicine Animals Diabetic Nephropathies Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology business.industry General Medicine 021001 nanoscience & nanotechnology biology.organism_classification medicine.disease Streptozotocin Gastrointestinal Microbiome Mice Inbred C57BL medicine.anatomical_structure Glucose chemistry medicine.symptom 0210 nano-technology business Dysbiosis medicine.drug |
| Zdroj: | International journal of biological macromolecules. 132 |
| ISSN: | 1879-0003 |
| Popis: | Dysbiosis of gut microbiota and low grade inflammation has gradually become a highly potential therapeutic agent for diabetic nephropathy (DN). It has been reported that a large number of polysaccharides have positive effects on DN, including Bupleurum polysaccharides. However, the mechanism remained unclear. This study selected two Bupleurum polysaccharides from different origins to investigate the potential relationship between kidney and gut. Diabetic mice model was established by streptozotocin (STZ, 100 mg/kg) and the treatment groups were treated with two Bupleurum polysaccharides (60 mg/kg) for 6 weeks, respectively. The results showed that the administration of Bupleurum polysaccharides ameliorated diabetic nephropathy induced by STZ. Blood glucose, blood creatinine and urine albumin were decreased after the oral administration of Bupleurum polysaccharides. And the dysbiosis of gut microbiota was modulated with higher diversity and gut protective microbiota. The gut barrier was also improved and the expression of inflammatory response both in kidney and colon was reduced. These results provided the evidence that modulating the gut microbiota and inflammation was involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice and laid the foundation for the deeper, specific mechanism research on the interaction between kidney and gut. |
| Databáze: | OpenAIRE |
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