Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis
| Autor: | Domenic P.J. Germano, Stuart T. Johnston, Edmund J. Crampin, James M. Osborne |
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| Rok vydání: | 2022 |
| Předmět: |
Statistics and Probability
Cell Death General Immunology and Microbiology Applied Mathematics Quantitative Biology - Tissues and Organs General Medicine Epithelium General Biochemistry Genetics and Molecular Biology Cell Movement Modeling and Simulation FOS: Biological sciences Cell Adhesion Homeostasis General Agricultural and Biological Sciences Tissues and Organs (q-bio.TO) |
| DOI: | 10.48550/arxiv.2205.04592 |
| Popis: | The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to be stable, cell renewal, cell migration and cell death must be finely balanced. Moreover, a tissue's shape must remain relatively unchanged. Simple epithelial tissues occur in various structures throughout the body, such as the endothelium, mesothelium, linings of the lungs, saliva and thyroid glands, and gastrointestinal tract. Despite the prevalence of simple epithelial tissues, there are few models which accurately describe how these tissues maintain a stable structure. Here, we present a novel, 3D, deformable, multilayer, cell-centre model of a simple epithelium. Cell movement is governed by the minimisation of a bending potential across the epithelium, cell-cell adhesion, and viscous effects. We show that the model is capable of maintaining a consistent tissue structure while undergoing self renewal. We also demonstrate the model's robustness under tissue renewal, cell migration and cell removal. The model presented here is a valuable advancement towards the modelling of tissues and organs with complex and generalised structures. |
| Databáze: | OpenAIRE |
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