White Matter Injuries in Mild Traumatic Brain Injury and Posttraumatic Migraines: Diffusion Entropy Analysis
| Autor: | Joseph Delic, Marion A. Hughes, Saeed Fakhran, Lea M. Alhilali, Serter Gumus |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Traumatic brain injury Entropy Migraine Disorders Poison control 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Fractional anisotropy Brain Injuries Traumatic medicine Humans Radiology Nuclear Medicine and imaging Child Retrospective Studies Receiver operating characteristic business.industry Retrospective cohort study Middle Aged medicine.disease White Matter medicine.anatomical_structure Diffusion Tensor Imaging Migraine Cardiology Female Medical emergency Headaches medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Radiology. 279(3) |
| ISSN: | 1527-1315 |
| Popis: | Purpose To determine the performance of Shannon entropy (SE) as a diagnostic tool in patients with mild traumatic brain injury (mTBI) with posttraumatic migraines (PTMs) and those without PTMs on the basis of analysis of fractional anisotropy (FA) maps. Materials and Methods The institutional review board approved this retrospective study, with waiver of informed consent. FA maps were obtained and neurocognitive testing was performed in 74 patients with mTBI (57 with PTM, 17 without PTM). FA maps were obtained in 22 healthy control subjects and in 20 control patients with migraine headaches. Mean FA and SE were extracted from total brain FA histograms and were compared between patients with mTBI and control subjects and between patients with and those without PTM. Mean FA and SE were correlated with clinical variables and were used to determine the areas under the receiver operating characteristic curve (AUCs) and likelihood ratios for mTBI and development of PTM. Results Patients with mTBI had significantly lower SE (P < .001) and trended toward lower mean FA (P = .07) compared with control subjects. SE inversely correlated with time to recovery (TTR) (r = -0.272, P = .02). Patients with mTBI with PTM had significantly lower SE (P < .001) but not mean FA (P = .15) than did other patients with mTBI. SE provided better discrimination between patients with mTBI and control subjects than mean FA (AUC = 0.92; P = .01), as well as better discrimination between patients with mTBI with PTM and those without PTM (AUC = 0.85; P < .001). SE of less than 0.751 resulted in a 16.1 increased likelihood of having experienced mTBI and a 3.2 increased likelihood of developing PTM. Conclusion SE more accurately reveals mTBI than mean FA, more accurately reveals those patients with mTBI who develop PTM, and inversely correlates with TTR. (©) RSNA, 2016. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|