Enhanced binding of lymphocytes from patients with multiple sclerosis to tumour necrosis factor-alpha (TNF-α)-treated endothelial monolayers: associations with clinical relapse and adhesion molecule expression
| Autor: | G. D. Perkin, A. J. Vora, K. A. Brown, T. McCOY, Dudley C. Dumonde |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Integrins Umbilical Veins Multiple Sclerosis Endothelium Lymphocyte Immunology Receptors Lymphocyte Homing Inflammation Integrin alpha4beta1 CD49d Peripheral blood mononuclear cell Cell–cell interaction Cell Adhesion medicine Humans Immunology and Allergy Lymphocytes Rapid Publications Cells Cultured Tumor Necrosis Factor-alpha Cell adhesion molecule business.industry Middle Aged Endothelial stem cell medicine.anatomical_structure Leukocytes Mononuclear Female Endothelium Vascular medicine.symptom business Cell Adhesion Molecules |
| Zdroj: | Clinical and Experimental Immunology. 105:155-162 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.1996.d01-721.x |
| Popis: | This study investigated the adherent properties and adhesion molecule expression of blood mononuclear cells (MNC) from a total of 84 patients with multiple sclerosis (MS). The MNC from MS patients were significantly more adherent than cells from normal healthy subjects to endothelial monolayers pretreated with 0.01 U/ml TNF-α (103% increase; P = 0.002), 0.1 U/ml TNF-α (80% increase; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|