A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt(IV) Prodrug Activation
| Autor: | Mark Bradley, Andrew R. Mount, Alessia Gambardella, Alan F. Murray, Daniel J. Norman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Programmed cell death
010405 organic chemistry Singlet oxygen Cell Dual mode chemistry.chemical_element General Chemistry General Medicine Prodrug 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Ruthenium chemistry.chemical_compound medicine.anatomical_structure chemistry Photocatalysis medicine |
| Zdroj: | Norman, D, Gambardella, A, Mount, A, Murray, A & Bradley, M 2019, ' A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt(IV) Prodrug Activation ', Angewandte Chemie International Edition, vol. 58, no. 40, pp. 14189-14192 . https://doi.org/10.1002/anie.201908511 |
| Popis: | A ruthenium-based mitochondrial-targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of PtIV prodrugs into their active PtII counterparts, and drives the generation of singlet oxygen was designed. This dual mode of action drives two orthogonal cancer-cell killing mechanisms with temporal and spatial control. The designed photosensitiser was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin-resistance. |
| Databáze: | OpenAIRE |
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