Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid
| Autor: | Ken-ichi Mukaisho, Takashi Fujimura, Tetsuo Ohta, Sachio Fushida, Tomoya Tsukada, Katsunobu Oyama, Shinichi Harada, Tomoharu Miyashita, Hidehiro Tajima, Eisuke Ojima, Takanori Hattori, Jun Kinoshita |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms medicine.drug_class Antineoplastic Agents Adenocarcinoma Chemoprevention Gastroenterology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Esophagus Metaplasia Internal medicine medicine Animals CDX2 Transcription Factor Rats Wistar CDX2 Homeodomain Proteins Microscopy Bile acid Histocytochemistry business.industry Gene Expression Profiling Ursodeoxycholic Acid NF-kappa B Cholic acid General Medicine medicine.disease Immunohistochemistry Ursodeoxycholic acid Disease Models Animal Treatment Outcome medicine.anatomical_structure chemistry Barrett's esophagus medicine.symptom business Esophagitis Transcription Factors medicine.drug |
| Zdroj: | Clinical and Experimental Medicine. 15:343-350 |
| ISSN: | 1591-9528 |
| Popis: | Reflux of bile acid into the esophagus induces esophagitis, inflammation-stimulated hyperplasia, metaplasia such as Barrett’s esophagus (BE), and esophageal adenocarcinoma (EAC). Caudal-type homeobox 2 (Cdx2) via nuclear factor (NF)-κB induced by bile acid is an important factor in the development of BE and EAC. In colorectal cancer, experimental data suggest a chemopreventive effect of ursodeoxycholic acid (UDCA). We hypothesized that UDCA may protect against the esophageal inflammation–metaplasia–carcinoma sequence by decreasing the overall proportion of the toxic bile acids. Wistar male rats that underwent a duodenoesophageal reflux procedure were divided into two groups. One group was given commercial chow (control group), and the other was given experimental chow containing UDCA (UDCA group). The animals were killed at 40 weeks after surgery, and their bile and esophagus were examined. In the UDCA group, the esophagitis was milder and the incidence of BE was significantly lower (p |
| Databáze: | OpenAIRE |
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