Current concepts regarding the effect of wound microbial ecology and biofilms on wound healing
| Autor: | J. William Costerton, Carrie E. Black |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Chronic wound
Male medicine.medical_treatment Administration Topical Occlusive Dressings Risk Assessment Microbiology Bioburden Anti-Infective Agents medicine Humans Wound Healing integumentary system Ecology business.industry Biofilm Biofilm matrix biochemical phenomena metabolism and nutrition Antimicrobial Bandages Occlusive dressing Treatment Outcome Debridement Debridement (dental) Biofilms Wound Infection Wounds and Injuries Surgery Female medicine.symptom business Wound healing |
| Zdroj: | The Surgical clinics of North America. 90(6) |
| ISSN: | 1558-3171 |
| Popis: | Biofilms are a collection of microbes that adhere to surfaces by manufacturing a matrix that shields them from environmental elements. Wound biofilms are difficult to evaluate clinically, and standard culture methods are inadequate for capturing the true bioburden present in the biofilm. New molecular techniques provide the means for rapid detection and evaluation of wound biofilms, and may prove to be useful in the clinical setting. Studies have shown that many commercial topical agents and wound dressings in use are ineffective against the biofilm matrix. At this stage, mechanical debridement appears to be essential in the eradication of a wound biofilm. Topical antimicrobial agents and antibiotics may be effective in the treatment of the wound bed after debridement in the prevention of biofilm reformation. |
| Databáze: | OpenAIRE |
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