Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy:Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group
Autor: | Petra J. van Houdt, Rick Keesman, Daniela Thorwarth, Uulke A. van der Heide, William A. Hall, Marielle E.P. Philippens, Jihong Wang, T Stanescu, Neelam Tyagi, Ernst S. Kooreman, Brigid A. McDonald, Clifton D. Fuller, Amita Shukla-Dave, Faisal Mahmood, Catherine Coolens, Andreas Wetscherek, Hina Saeed, Astrid L.H.M.W. van Lier |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Quantitative imaging Imaging biomarker Computer science medicine.medical_treatment Multicentre study Article 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Magnetic resonance imaging medicine Humans Medical physics Mr linac medicine.diagnostic_test Radiotherapy business.industry Image-guided Magnetic Resonance Imaging Radiation therapy Clinical trial 030104 developmental biology Oncology 030220 oncology & carcinogenesis Radiation Oncology business Quality assurance Mri guided Biomarkers Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] Radiotherapy Image-Guided |
Zdroj: | van Houdt, P J, Saeed, H, Thorwarth, D, Fuller, C D, Hall, W A, McDonald, B A, Shukla-Dave, A, Kooreman, E S, Philippens, M E P, van Lier, A L H M W, Keesman, R, Mahmood, F, Coolens, C, Stanescu, T, Wang, J, Tyagi, N, Wetscherek, A & van der Heide, U A 2021, ' Integration of quantitative imaging biomarkers in clinical trials for MR-guided radiotherapy : Conceptual guidance for multicentre studies from the MR-Linac Consortium Imaging Biomarker Working Group ', European Journal of Cancer, vol. 153, pp. 64-71 . https://doi.org/10.1016/j.ejca.2021.04.041 European Journal of Cancer, 153, 64-71 Eur J Cancer European Journal of Cancer, 153, pp. 64-71 |
ISSN: | 0959-8049 |
Popis: | Quantitative imaging biomarkers (QIBs) derived from MRI techniques have the potential to be used for the personalised treatment of cancer patients. However, large-scale data are missing to validate their added value in clinical practice. Integrated MRI-guided radiotherapy (MRIgRT) systems, such as hybrid MRI-linear accelerators, have the unique advantage that MR images can be acquired during every treatment session. This means that high-frequency imaging of QIBs becomes feasible with reduced patient burden, logistical challenges, and costs compared to extra scan sessions. A wealth of valuable data will be collected before and during treatment, creating new opportunities to advance QIB research at large. The aim of this paper is to present a roadmap towards the clinical use of QIBs on MRIgRT systems. The most important need is to gather and understand how the QIBs collected during MRIgRT correlate with clinical outcomes. As the integrated MRI scanner differs from traditional MRI scanners, technical validation is an important aspect of this roadmap. We propose to integrate technical validation with clinical trials by the addition of a quality assurance procedure at the start of a trial, the acquisition of in vivo test-retest data to assess the repeatability, as well as a comparison between QIBs from MRIgRT systems and diagnostic MRI systems to assess the reproducibility. These data can be collected with limited extra time for the patient. With integration of technical validation in clinical trials, the results of these trials derived on MRIgRT systems will also be applicable for measurements on other MRI systems. |
Databáze: | OpenAIRE |
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