An IL-13 promoter polymorphism associated with increased risk of allergic asthma
| Autor: | van der Zee Js, de Groot Er, S O Stapel, L. C. M. Boeije, van Tuyl Sa, van der Pouw Kraan Tc, A.H.F. Bakker, Lucien A. Aarden, Cornelis L. Verweij, van Veen A |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Genotype
Immunology Promoter polymorphism Immunoglobulin E Risk Factors Genetics medicine Eosinophilia Humans Nuclear protein Promoter Regions Genetic Genetics (clinical) DNA Primers Interleukin-13 Polymorphism Genetic biology Base Sequence Allergic asthma DNA Asthma respiratory tract diseases Increased risk Case-Control Studies Interleukin 13 biology.protein medicine.symptom |
| Zdroj: | Genes and immunity. 1(1) |
| ISSN: | 1466-4879 |
| Popis: | IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|