Ultrastructural and Biochemical Evaluation of Adrenal Medullary Hyperplasia and Pheochromocytoma in Aged Bulls
| Autor: | J. T. Yarrington, Charles C. Capen |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
0301 basic medicine Aging endocrine system medicine.medical_specialty Pathology Epinephrine endocrine system diseases 040301 veterinary sciences Urinary system Adrenal Gland Neoplasms Cattle Diseases Pheochromocytoma 0403 veterinary science Norepinephrine Vanilmandelic Acid 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals Vanillylmandelic acid Hyperplasia General Veterinary business.industry Thyroid 04 agricultural and veterinary sciences medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Adrenal Medulla Chromaffin cell Cattle Adrenal medulla business medicine.drug |
| Zdroj: | Veterinary Pathology. 18:316-325 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/030098588101800304 |
| Popis: | Pheochromocytomas and adrenal medullary hyperplasia were investigated ultrastructurally and by assaying catecholamines in tissue and urine. Three of seven bulls had concomitant thyroid C-cell neoplasms and normal parathyroid glands. Pheochromocytomas were either bilateral or unilateral, and were composed of large chromaffin cells predominantly in the storage phase of the secretory cycle. Two pheochromocytomas were composed of cells with ultrastructural characteristics of the epinephrine-secreting type and contained round secretory granules of low electron density. The norepinephrine-secreting type of chromaffin cell predominated in one pheochromocytoma and had storage granules with an electron-dense, eccentric core and a wide submembranous space. Two pheochromocytomas were composed of a mixture of epinephrine- and norepinephrine-secreting cells. Adrenal medullary hyperplasia in four bulls consisted of multinodular or diffuse areas of hyperchromatic chromaffin cells that were non-encapsulated, and compressed adjacent cortical tissue. Tissue and urinary concentrations of norepinephrine were increased in bulls with adrenal medullary hyperplasia or pheochromocytoma, but urinary vanillylmandelic acid and unconjugated epinephrine levels were not different from those of control bulls with a normal adrenal medulla. |
| Databáze: | OpenAIRE |
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