First Aldehyde-Functionalized Poly(2-oxazoline)s for Chemoselective Ligation
| Autor: | Robert Luxenhofer, Christian Taubmann, Rainer Jordan, Sonia Cesana |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Aldehydes Polymers and Plastics Polymers Chemistry Cationic polymerization Dioxolanes Bioengineering Oxazoline Degree of polymerization Aldehyde Ring-opening polymerization Biomaterials chemistry.chemical_compound Polymerization Polymer chemistry Materials Chemistry Copolymer Organic chemistry Living polymerization Oxazoles Biotechnology |
| Zdroj: | Macromolecular Bioscience. 5:603-612 |
| ISSN: | 1616-5195 1616-5187 |
| DOI: | 10.1002/mabi.200500059 |
| Popis: | A protected aldehyde-functionalized 2-oxazoline, 2-[3-(1,3)-dioxolan-2-ylpropyl]-2-oxazoline (DPOx), was synthesized from commercially available compounds in high yields. The polymerization of DPOx with different initiators proceeds via a living iionic mechanism; thus, the polymers were of low polydispersity and the degree of polymerization could be precisely adjusted. Copolymerization with 2-methyl-2-oxazoline gave water-soluble statistical copolymers. Hydrolysis of the homo- and copolymers resulted in well-defined aldehyde-bearing poly(2-oxazo-line)s. The aldehyde side functions reacted quantitatively with an amino-oxy compound to form the corresponding oxime. |
| Databáze: | OpenAIRE |
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