Salivary procalcitonin and periodontitis in diabetes
| Autor: | D.J. DeNucci, Robert S. Redman, Carol W. Bassim, K. L. Becker, E. S. Nylén |
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| Rok vydání: | 2008 |
| Předmět: |
Calcitonin
Male Saliva medicine.medical_specialty Calcitonin Gene-Related Peptide Type 2 diabetes Severe periodontitis Gastroenterology Severity of Illness Index Procalcitonin Statistics Nonparametric Reference Values Internal medicine Diabetes mellitus medicine Humans Protein Precursors Periodontitis General Dentistry business.industry Case-control study Middle Aged medicine.disease Treatment Outcome Diabetes Mellitus Type 2 Case-Control Studies Hyperglycemia Immunology Periodontal Index business Biomarkers Follow-Up Studies |
| Zdroj: | Journal of dental research. 87(7) |
| ISSN: | 0022-0345 |
| Popis: | Periodontitis and type 2 diabetes are co-morbid conditions, both characterized by infectious susceptibility. We investigated procalcitonin (ProCT) levels in the serum and saliva of persons with periodontitis and type 2 diabetes (n = 20), to determine if these levels are altered by periodontitis activity or by hyperglycemia. Persons with severe periodontitis showed higher levels of salivary-ProCT than did those with moderate periodontitis (241 ± 71 vs. 77 ± 516 pg/mL, p = 0.02) and higher levels than did healthy control individuals (118 ± 26 pg/mL, p = 0.05). Salivary-ProCT levels were correlated with bleeding-on-probing (r = 0.45, p = 0.05), as well as with HgbA1c (r = 0.49, p = 0.03). Salivary levels of ProCT were higher than serum levels for the periodontitis/diabetes group (152 ± 37 vs. 78 ± 17 pg/mL, p = 0.02) and the control group (118 ± 146 vs. 48 ± 17 pg/mL, p = 0.01). Persons with periodontitis and type 2 diabetes have salivary-ProCT levels that reflect their degree of periodontitis activity and hyperglycemia. This study demonstrates, for the first time, the presence of procalcitonin (ProCT), an established serum marker of infection, in saliva. |
| Databáze: | OpenAIRE |
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