Prognostic value and interobserver agreement of endoscopic ultrasonography for superficial squamous cell carcinoma of the esophagus: a prospective study
| Autor: | Tomoharu Yoshida, Kiwamu Okita, Naori Takeo, Takeshi Okamoto, Toshiya Harada, Atsuyoshi Hirano, Toyokazu Kawano, Hideo Yanai |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Gastroenterology Sensitivity and Specificity Endosonography Endocrinology Internal medicine medicine Carcinoma Humans Neoplasm Invasiveness Prospective Studies Stage (cooking) Esophagus Prospective cohort study Aged Neoplasm Staging Aged 80 and over Observer Variation Esophageal disease business.industry Cancer Esophageal cancer Middle Aged medicine.disease Prognosis Survival Analysis digestive system diseases medicine.anatomical_structure Oncology Epidermoid carcinoma Carcinoma Squamous Cell Female Radiology business |
| Zdroj: | International journal of gastrointestinal cancer. 34(1) |
| ISSN: | 1537-3649 |
| Popis: | Background and Aims. Submucosal invasion of superficial esophageal cancer (SEC) is related to the prognosis. We prospectively analyzed outcomes of SEC in patients staged by endoscopic ultrasonography (EUS). Patients and Methods. We staged 31 endoscopically diagnosed SEC cases using a 20/15-MHz thin probe. The EUS tumor stage was classified as EUSM (limited within mucosa), EUS-SM (with submucosal invasion), or EUS-MP over (invading the muscularis propria or deeper). Lymph node metastasis and 2-yr survival were analyzed according to the EUS tumor stage in 29 squamous cell carcinoma cases. Interobserver agreement of the EUS stage was tested between the examiner and a blind reviewer. Results. Lymph node metastasis was significantly frequent in the EUS-SM group (8 of 18 cases [44.4%]) compared with the EUS-M group (1 of 10 cases [10%]) (p=0.03). Patient survival at 2 yr after initial therapy was 72.2% in the EUS-SM group and 90% in the EUS-M group. Death from cancer was noted only in the EUS-SM group (three cases). The accuracy rates of EUS tumor staging were 74.1% by the examiner and 66.7% by the blind reviewer, with moderate interobserver agreement (κ=0.46). Conclusions. Thin-probe EUS can classify SEC into two groups: the EUS-M group with excellent outcome and the EUS-SM group with a significant risk of lymph node metastasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink