Relationships of Language Lateralization with Diffusion Tensor Imaging Metrics of Corpus Callosum, Tumor Grade, and Tumors Distance to Language-Eloquent Areas in Glial Neoplasms
| Autor: | Gizem Timocin, Ayse Aralasmak, Ali Toprak |
|---|---|
| Přispěvatelé: | TOPRAK, ALİ |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent computer.software_genre Corpus callosum Timocin G. TOPRAK A. Aralasmak A. -Relationships of Language Lateralization with Diffusion Tensor Imaging Metrics of Corpus Callosum Tumor Grade and Tumors Distance to Language-Eloquent Areas in Glial Neoplasms- JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY cilt.44 sa.6 ss.956-968 2020 Corpus Callosum Young Adult Text mining Voxel Preoperative Care Fractional anisotropy medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Language Retrospective Studies Brain Mapping Neoplasm Grading medicine.diagnostic_test Brain Neoplasms business.industry Glioma Middle Aged Diffusion Tensor Imaging Female Functional magnetic resonance imaging business computer Diffusion MRI |
| Popis: | Purpose The aim of the study was to search relationships between language lateralization and corpus callosum (CC) connectivity, tumor grade, and tumors distance to language-eloquent areas in glial neoplasms. Materials and methods The functional magnetic resonance imaging and CC diffusion tensor imaging (DTI) metrics of 42 patients with glial neoplasm were evaluated for relationships of language lateralization (left, right, and bilateral) with CC DTI metrics (tracts number, voxel, volume, length, fractional anisotropy [FA], and apparent diffusion coefficient), tumor grade, and tumors distance to language-eloquent areas and relationships of CC DTI metrics with tumor grade. Kruskal-Wallis, Mann-Whitney U, and χ tests were used. All were repeated in 26 patients with left hemispheric masses. Results In glial masses, language bilateralism was more common than normal population and more pronounced in low grade than high grade. In right lateralism and bilateralism, tumor settlement nearby language-eloquent areas was more common. In the left lateralism, highest CC tract number, higher tumor grade, and more remote tumor settlements were noted. There was no relationship between CC DTI metrics and tumor grade but increase in CC tracts number and FA with increasing tumor grade. Conclusions Increased bilateralism in glial masses than normal population and in low grade tumors than high grade and increased nearby tumor settlement in right lateralism and bilateralism support interhemispheric reorganization and plasticity. This is more pronounced in low grade because of higher life span. Highest CC tract number, higher tumor grade, and more remote tumor settlement in left lateralized group suggest intact CC integrity with limited hemispheric destruction. Increasing CC tracts number and FA with increasing tumor grade support preserved CC integrity in the shorter life span of high-grade tumors. |
| Databáze: | OpenAIRE |
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