Repeated Methamphetamine Administration Differentially Alters Fos Expression in Caudate-Putamen Patch and Matrix Compartments and Nucleus Accumbens

Autor: Courtney M. Cameron, Terry E. Robinson, Jakub P. Jedynak
Rok vydání: 2012
Předmět:
Psychopharmacology
Striosome
lcsh:Medicine
Gene Expression
Striatum
Nucleus Accumbens
Methamphetamine
Rats
Sprague-Dawley
Behavioral Neuroscience
0302 clinical medicine
Molecular Cell Biology
lcsh:Science
Sensitization
0303 health sciences
Multidisciplinary
Neurochemistry
medicine.anatomical_structure
Behavioral Pharmacology
Anesthesia
Medicine
Female
Proto-Oncogene Proteins c-fos
Research Article
medicine.drug
Drugs and Devices
Neural Networks
Nucleus accumbens
Biology
Signaling Pathways
Molecular Genetics
03 medical and health sciences
Genetics
medicine
Biological neural network
Animals
030304 developmental biology
Motor Systems
Compartment (ship)
lcsh:R
Ventral striatum
Computational Biology
Rats
Neuroanatomy
Cellular Neuroscience
lcsh:Q
Molecular Neuroscience
Neuroscience
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e34227 (2012)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034227
Popis: Background The repeated administration of psychostimulant drugs produces a persistent and long-lasting increase (“sensitization”) in their psychomotor effects, which is thought to be due to changes in the neural circuitry that mediate these behaviors. One index of neuronal activation used to identify brain regions altered by repeated exposure to drugs involves their ability to induce immediate early genes, such as c-fos. Numerous reports have demonstrated that past drug experience alters the ability of drugs to induce c-fos in the striatum, but very few have examined Fos protein expression in the two major compartments in the striatum—the so-called patch/striosome and matrix. Methodology/Principal Findings In the present study, we used immunohistochemistry to investigate the effects of pretreatment with methamphetamine on the ability of a subsequent methamphetamine challenge to induce Fos protein expression in the patch and matrix compartments of the dorsolateral and dorsomedial caudate-putamen and in the ventral striatum (nucleus accumbens). Animals pretreated with methamphetamine developed robust psychomotor sensitization. A methamphetamine challenge increased the number of Fos-positive cells in all areas of the dorsal and ventral striatum. However, methamphetamine challenge induced Fos expression in more cells in the patch than in the matrix compartment in the dorsolateral and dorsomedial caudate-putamen. Furthermore, past experience with methamphetamine increased the number of methamphetamine-induced Fos positive cells in the patch compartment of the dorsal caudate putamen, but not in the matrix or in the core or shell of the nucleus accumbens. Conclusions/Significance These data suggest that drug-induced alterations in the patch compartment of the dorsal caudate-putamen may preferentially contribute to some of the enduring changes in brain activity and behavior produced by repeated treatment with methamphetamine.
Databáze: OpenAIRE
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