Autoantibodies Against Amyloid and Glial-Derived Antigens are Increased in Serum and Cerebrospinal Fluid of Lewy Body-Associated Dementias

Autor: Markus Langkamp, Daniela Berg, Thomas Gasser, Jana Godau, Stephanie C. Hörnig, Kathrin Brockmann, Matthis Synofzik, Walter Maetzler, Arthur Melms
Rok vydání: 2011
Předmět:
blood [Frontotemporal Dementia]
Male
cerebrospinal fluid [Frontotemporal Dementia]
cerebrospinal fluid [Lewy Body Disease]
immunology [Peptide Fragments]
immunology [alpha-Synuclein]
biology
General Neuroscience
S100 Proteins
General Medicine
amyloid beta-protein (1-42)
immunology [Amyloid beta-Peptides]
cerebrospinal fluid [Alzheimer Disease]
Psychiatry and Mental health
Clinical Psychology
Frontotemporal Dementia
alpha-Synuclein
Female
immunology [Myelin Basic Protein]
Myelin Proteins
Frontotemporal dementia
Lewy Body Disease
Enzyme-Linked Immunosorbent Assay
S100 Calcium Binding Protein beta Subunit
Myelin oligodendrocyte glycoprotein
blood [Alzheimer Disease]
Alzheimer Disease
mental disorders
medicine
Humans
Dementia
ddc:610
Nerve Growth Factors
S100B protein
human
Vascular dementia
Aged
Autoantibodies
immunology [Nerve Growth Factors]
Amyloid beta-Peptides
Lewy body
blood [Lewy Body Disease]
Dementia with Lewy bodies
business.industry
MOG protein
human
Autoantibody
Myelin Basic Protein
medicine.disease
immunology [S100 Proteins]
Peptide Fragments
nervous system diseases
Myelin basic protein
cerebrospinal fluid [Autoantibodies]
nervous system
Immunology
biology.protein
immunology [Myelin Proteins]
blood [Autoantibodies]
Myelin-Oligodendrocyte Glycoprotein
Geriatrics and Gerontology
business
Zdroj: Journal of Alzheimer's disease 26(1), 171-179 (2011). doi:10.3233/JAD-2011-110221
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-2011-110221
Popis: There is increasing evidence that in Lewy body-associated dementias (encompassing Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB)), the adaptive immune system is altered and the degenerative process includes glial cells in addition to neuronal structures. We therefore aimed to determine levels of autoantibodies against amyloid and glial-derived structures in these dementia types. Using a newly developed Enzyme-linked immunosorbent assay (ELISA), we measured levels of IgG autoantibodies against neuronal and glial structures in serum and cerebrospinal fluid of a total of 91 subjects (13 PDD, 14 DLB, 11 Alzheimer's disease (AD), 11 frontotemporal dementia (FTD), 11 vascular dementia patients (VaD), and 31 healthy controls). Autoantibody levels against α-synuclein, amyloid-β₄₂ (Aβ₄₂), myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP), and S100B were determined. In all groups, autoantibody levels were about three magnitudes higher in serum than in CSF. Serum autoantibody levels against α-synuclein, Aβ₄₂, MOG, MBP, and S100B were higher in PDD/DLB compared to tau-associated dementias (AD, FTD), VaD, and controls, respectively, with most of them reaching highly significant p-values. In cerebrospinal fluid (CSF), levels of antibodies against oligodendrocyte-derived antigens (MOG, MBP) were significantly increased in PDD/DLB. Increased levels of autoantibodies against both neuronal- and glial-derived antigens in serum and CSF of Lewy body-associated dementias indicate an altered activity of the adaptive immune system in these dementia types. The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated.
Databáze: OpenAIRE
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