Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer
| Autor: | Gulen Dogusoy, Yildiz Dincer, Tülay Akçay, Osman Baran Tortum |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Antioxidant Physiology medicine.medical_treatment Pharmacology Nitric Oxide Severity of Illness Index Antioxidants Nitric oxide Superoxide dismutase chemistry.chemical_compound Nitrate Stomach Neoplasms Leukocytes medicine Humans Nitrite Stomach cancer Nitrites Neoplasm Staging chemistry.chemical_classification Glutathione Peroxidase Nitrates biology Superoxide Dismutase Glutathione peroxidase Gastroenterology Cancer Middle Aged medicine.disease chemistry Disease Progression biology.protein Female Biomarkers |
| Zdroj: | Digestive Diseases and Sciences. 51:1367-1370 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor. |
| Databáze: | OpenAIRE |
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