Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis
| Autor: | Yangki Park, Keunhong Jeong, Pil Seok Chae, Seung Hong Choi, Hye Rim Cho |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Stereochemistry
Cell Apoptosis Cyclams Cleavage (embryo) Catalysis Cell Line Coordination Complexes Heterocyclic Compounds Insulin-Secreting Cells Materials Chemistry medicine Animals Humans Cytotoxicity Chemistry Metals and Alloys Cobalt General Chemistry Islet Amyloid Polypeptide Rats Surfaces Coatings and Films Electronic Optical and Magnetic Materials medicine.anatomical_structure Ceramics and Composites Copper |
| Zdroj: | Chem. Commun.. 48:588-590 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c1cc16293d |
| Popis: | Cleavage agents showed cleavage yields as much as 9-14%, which does not sufficiently support the agents' protection of β-cells from the cytotoxicity of h-IAPP. INS-1 cell tests were carried out to better understand the potential of using these cleavage agents as drug candidates. This study provides the firm basis for clinical applicability of these cleavage agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|