Dose-Dependent Acute Effects of Passive Smoking on Left Ventricular Cardiac Functions in Healthy Volunteers
| Autor: | Cemil Zencir, Mikail Yarlioglues, Idris Ardic, Abdurrahman Oguzhan, Hatice Yarlioglues, Mustafa Duran, Ali Dogan, Mehtap Ozdogru, Bahadir Sarli, Orhan Dogdu, Mehmet Gungor Kaya, Hacı Ahmet Kasapkara, Mahmut Akpek, Ibrahim Ozdogru |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Acute effects Passive smoking Systole Diastole Hemodynamics medicine.disease_cause Ventricular Function Left General Biochemistry Genetics and Molecular Biology Group B chemistry.chemical_compound Healthy volunteers Humans Medicine Lactic Acid Smoke Inhalation Exposure business.industry General Medicine Echocardiography Doppler Carboxyhemoglobin chemistry Health Anesthesia Heart Function Tests Female Tobacco Smoke Pollution business |
| Zdroj: | Journal of Investigative Medicine. 60:517-522 |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.2310/jim.0b013e31823e9fb1 |
| Popis: | Objective We have previously shown that acute passive smoking impaired left ventricular diastolic function in healthy volunteers. The aim of this study was to determine whether length of exposure and/or ambient smoke concentration is the key determinant of this outcome. Methods We measured blood carboxyhemoglobin (COHb)and lactate level to investigate the acute effects of passive smoking on tissue oxygenation. A total of 90 healthy nonsmoker volunteers were prospectively enrolled into the study. Each of 30 subjects were exposed to carbon monoxide (CO) less than 5.0 ppm smoke in group A for 30 minutes, to CO 5 to 10 ppm smoke in group B for 30 minutes, and to CO less than 5.0 ppm smoke in group C for 60 minutes. Hemodynamic parameters were obtained, blood samples for measuring COHb and lactate levels were taken and echocardiographic examinations were performed at baseline and after exposure to passive smoking. Results Mean ± SD CO levels in groups A, B, and C were 4.2 ± 0.5 ppm, 9.2 ± 0.3 ppm, and 4.1 ± 0.8 ppm, respectively. There was no change in left ventricular systolic functions in all groups. Left ventricular diastolic functions were impaired in groups B and C, whereas no change was observed in group A. Carboxyhemoglobin and lactate levels increased after passive smoking in groups B and C. However, group B had significantly higher COHb and lactate levels compared to group C ( P < 0.001). Conclusions Our results suggested that passive smoking at a certain dose in relation with length of exposure and ambient smoke concentration seems to cause relative left ventricular diastolic dysfunction. |
| Databáze: | OpenAIRE |
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