Does mitotic rate predict sentinel lymph node metastasis or survival in patients with intermediate and thick melanoma?
| Autor: | Robert C.G. Martin, Charles R. Scoggins, Kelly M. McMasters, Michael P. Mays, Lee Hagendoorn, Brooke Ginter, Brent A. Roach, Alison L. Burton, Arnold J. Stromberg |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Skin Neoplasms Sentinel lymph node Urology Disease-Free Survival Metastasis Young Adult Biopsy medicine Mitotic Index Humans Melanoma Aged Randomized Controlled Trials as Topic medicine.diagnostic_test business.industry Sentinel Lymph Node Biopsy Mitotic rate Cancer General Medicine Sentinel node Middle Aged medicine.disease Surgery Survival Rate Lymphatic Metastasis Female business |
| Zdroj: | American journal of surgery. 200(6) |
| ISSN: | 1879-1883 |
| Popis: | Background The significance of mitotic rate (MR) in melanoma remains controversial. Methods In this retrospective analysis of a prospective randomized trial that included patients with melanoma of 1.0 mm or greater, all patients underwent wide excision and sentinel node (sentinel lymph node [SLN]) biopsy. Univariate and multivariate analyses were performed to evaluate factors predictive of disease-free survival (DFS) and overall survival (OS). Results A total of 551 patients had MR reported. A cut-off point of 6 mitoses/mm 2 best discriminated DFS and OS: 455 patients (82.6%) had MR less than 6/mm 2 . SLN were tumor-positive in 14.7% of low MR versus 31.3% of high MR patients ( P = .0003). There were significant differences in DFS ( P = .0014) and OS ( P = .0002) between the 2 groups, however, MR failed to remain significant in the multivariate model. Conclusions MR is weakly predictive of SLN status but it is not an independent predictor of survival for melanomas 1.0 mm or thicker. |
| Databáze: | OpenAIRE |
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