Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: A case report and review of the literature
Autor: | Gabriel C. Caponetti, Kayla Kendric, Gaurav Goyal, Austin Huy Nguyen |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Colon Cell of origin Biology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Ileum immune system diseases hemic and lymphatic diseases medicine Humans Aged breakpoint cluster region Germinal center Cell Biology medicine.disease Hodgkin Disease Lymphoma Composite Lymphoma 030104 developmental biology 030220 oncology & carcinogenesis Monoclonal Immunohistochemistry Immunoglobulin heavy chain Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma |
Zdroj: | Pathology - Research and Practice. 212:1179-1190 |
ISSN: | 0344-0338 |
Popis: | Composite lymphoma (CL) is an infrequently diagnosed entity in which two or more distinct types of lymphomas occur synchronously in the same organ or anatomical site. Most commonly, CLs are composed of two non-Hodgkin B-cell lymphomas. We present a case of a composite lymphoma with diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS) and classical Hodgkin lymphoma (CHL) components involving the terminal ileum, colon and pericolic lymph nodes. Immunohistochemical evaluation for determination of cell of origin of the DLBCL-NOS component indicated a germinal center B-cell subtype. Immunoglobulin heavy chain fragment length analysis revealed identical dominant monoclonal peaks on the DH1-6-JH reaction, and also a dominant monoclonal peak observed only in the framework II reaction done on the CHL component, indicating a partial clonal relationship between the two components. Additionally, a review of the available literature reveals a total of 20 previously reported cases of CL with DLBCL-NOS and CHL components, and most of the tested cases showed clonal relationship between the two components. The overall findings indicate that in most cases, the two components of CL with DLBCL-NOS and CHL components are clonally related, and suggest a shared origin from a common B-cell precursor. |
Databáze: | OpenAIRE |
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