Overcoming bacterial physical defenses with molecule-like ultrasmall antimicrobial gold nanoclusters
| Autor: | David Tai Leong, Jianping Xie, Magdiel Inggrid Setyawati, Kaiyuan Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Size effects
0206 medical engineering Biomedical Engineering Nanotechnology 02 engineering and technology behavioral disciplines and activities Article Molecule-like properties Nanoclusters Biomaterials Metal mental disorders lcsh:TA401-492 Molecule Gold nanoparticles Gold nanoclusters lcsh:QH301-705.5 Chemistry Ligand 021001 nanoscience & nanotechnology Antimicrobial Antimicrobial agents 020601 biomedical engineering Membrane lcsh:Biology (General) Colloidal gold visual_art Reactive oxygen species generation visual_art.visual_art_medium lcsh:Materials of engineering and construction. Mechanics of materials 0210 nano-technology Biotechnology |
| Zdroj: | Bioactive Materials, Vol 6, Iss 4, Pp 941-950 (2021) Bioactive Materials |
| Popis: | The size of metal nanoparticles (NPs) is crucial in their biomedical applications. Although abundant studies on the size effects of metal NPs in the range of 2–100 nm have been conducted, the exploration of the ultrasmall metal nanoclusters (NCs) of ~1 nm in size with unique features is quite limited. We synthesize three different sized gold (Au) NCs of different Au atom numbers and two bigger sized Au NPs protected by the same ligand to study the size influence on antimicrobial efficacy. The ultrasmall Au NCs can easily traverse the cell wall pores to be internalized inside bacteria, inducing reactive oxygen species generation to oxidize bacterial membrane and disturb bacterial metabolism. This explains why the Au NCs are antimicrobial while the Au NPs are non-antimicrobial, suggesting the key role of size in antimicrobial ability. Moreover, in contrast to the widely known size-dependent antimicrobial properties, the Au NCs of different atom numbers demonstrate molecule-like instead of size-dependent antimicrobial behavior with comparable effectiveness, indicating the unique molecule-like feature of ultrasmall Au NCs. Overcoming the bacterial defenses at the wall with ultrasmall Au NCs changes what was previously believed to harmless to the bacteria instead to a highly potent agent against the bacteria. Graphical abstract Image 1 Highlights • Size of nanomaterials plays a key role in biomedical applications, especially in antimicrobial behaviors. • The ultrasmall gold nanoclusters (Au NCs) less than 2 nm can easily traverse the cell wall pores to be internalized inside bacteria to kill bacteria. • The gold nanoparticles (Au NPs) are too big to be effectively internalized inside bacteria, failing to kill bacteria. • Au NCs of different atom numbers (i.e. different size) demonstrate molecule-like instead of size-dependent antimicrobial behavior. |
| Databáze: | OpenAIRE |
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