Increased Brain Activation During Working Memory in Cognitively Intact Adults With the APOE ε4 Allele
| Autor: | Laura A. Rabin, Robert B. Santulli, Alexander C. Mamourian, Dorothy R. Belloni, Thomas W. McAllister, Laura A. Flashman, Andrew J. Saykin, Heather A. Wishart, Stephen J. Guerin, C. Harker Rhodes |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Apolipoprotein E Elementary cognitive task medicine.medical_specialty Genotype Apolipoprotein E4 Apolipoprotein E3 Prefrontal Cortex Neuropsychological Tests Audiology Functional Laterality Apolipoproteins E Cognition Alzheimer Disease Memory Risk Factors Functional neuroimaging Parietal Lobe Task Performance and Analysis medicine Humans Prefrontal cortex Alleles Aged medicine.diagnostic_test Verbal Behavior Working memory Brain medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Female Alzheimer's disease Psychology Functional magnetic resonance imaging Neuroscience Psychomotor Performance |
| Zdroj: | American Journal of Psychiatry. 163:1603-1610 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Altered patterns of brain activity during cognitive tasks have been demonstrated using functional magnetic resonance imaging (fMRI) in mild cognitive impairment and Alzheimer's disease. However, there have been few studies of adults at genetic risk for Alzheimer's disease prior to the onset of symptoms. The purpose of this study was to determine whether brain activation patterns associated with working memory differ as a function of apolipoprotein E (APOE) genotype in cognitively intact adults.Participants were cognitively intact, healthy adults who completed genotyping, comprehensive neuropsychological testing, and structural and functional neuroimaging. Twenty-two participants had the APOE epsilon3/epsilon3 genotype, and 13 participants had the APOE epsilon3/epsilon4 genotype. The study employed an auditory verbal N-back task to probe working memory-related brain activity.The epsilon3/epsilon3 and epsilon3/epsilon4 groups did not differ in demographic characteristics, cognitive ability, mood, or in-scanner task performance. The epsilon3/epsilon4 group showed greater activity during working memory in the medial frontal and parietal regions bilaterally and in the right dorsolateral prefrontal cortex. There were no regions in which the epsilon3/epsilon3 group showed greater activation than the epsilon3/epsilon4 group.These results indicate that differences in brain activity are evident in cognitively intact individuals who are at risk for late-onset Alzheimer's disease by virtue of their APOE allele status. As neuroprotective interventions become available, early detection will increase in importance. The combination of genetic and functional neuroimaging strategies may prove useful for monitoring individuals at risk for Alzheimer's disease before the onset of cognitive symptoms. |
| Databáze: | OpenAIRE |
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