Deciphering the Genetic Architecture of Plant Virus Resistance by GWAS, State of the Art and Potential Advances
Autor: | Henri Desaint, Laurence Moreau, Valérie Schurdi-Levraud, Tristan Mary-Huard, Severine Monnot, Nathalie Boissot |
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Přispěvatelé: | Génétique et Amélioration des Fruits et Légumes (GAFL), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bayer Cropscience, Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) (GQE-Le Moulon), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biologie du fruit et pathologie (BFP), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
Rok vydání: | 2021 |
Předmět: |
0106 biological sciences
QH301-705.5 [SDV]Life Sciences [q-bio] Quantitative Trait Loci Context (language use) Genome-wide association study plant Computational biology Review virus Biology 01 natural sciences Linkage Disequilibrium Plant Viruses 03 medical and health sciences Plant virus [SDV.BV]Life Sciences [q-bio]/Vegetal Biology GWAS Biology (General) Allele 030304 developmental biology Disease Resistance 2. Zero hunger virus phytopathogène 0303 health sciences Resistance (ecology) Plant species diversity General Medicine Genetic architecture Plant Breeding virologie végétale 010606 plant biology & botany Genome-Wide Association Study |
Zdroj: | Cells Cells, MDPI, 2021, 10 (11), pp.3080. ⟨10.3390/cells10113080⟩ Cells, Vol 10, Iss 3080, p 3080 (2021) |
ISSN: | 2073-4409 |
Popis: | International audience; Growing virus resistant varieties is a highly effective means to avoid yield loss due to infection by many types of virus. The challenge is to be able to detect resistance donors within plant species diversity and then quickly introduce alleles conferring resistance into elite genetic backgrounds. Until now, mainly monogenic forms of resistance with major effects have been introduced in crops. Polygenic resistance is harder to map and introduce in susceptible genetic backgrounds, but it is likely more durable. Genome wide association studies (GWAS) offer an opportunity to accelerate mapping of both monogenic and polygenic resistance, but have seldom been implemented and described in the plant–virus interaction context. Yet, all of the 48 plant–virus GWAS published so far have successfully mapped QTLs involved in plant virus resistance. In this review, we analyzed general and specific GWAS issues regarding plant virus resistance. We have identified and described several key steps throughout the GWAS pipeline, from diversity panel assembly to GWAS result analyses. Based on the 48 published articles, we analyzed the impact of each key step on the GWAS power and showcase several GWAS methods tailored to all types of viruses. |
Databáze: | OpenAIRE |
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