Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature
| Autor: | Viktoriya Georgieva, Milena Peruhova, Gabriela Panayotova, Dorian Dikov, Monika Peshevska-Sekulovska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Russell body gastritis Russell bodies Plasma cell 03 medical and health sciences 0302 clinical medicine Biopsy Case report Gastric mucosa Medicine medicine.diagnostic_test biology business.industry Gastric lymphoma Gastroenterology General Medicine Helicobacter pylori biology.organism_classification medicine.disease Treatment medicine.anatomical_structure 030220 oncology & carcinogenesis Helicobacter pylori-negative 030211 gastroenterology & hepatology Chronic Inflammatory Infiltrate Gastritis medicine.symptom business Mature plasma cells |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | Background Russell body gastritis (RBG) is very rare type of chronic inflammation of gastric mucosa. The pathologic hallmark of the disease is Russell bodies (RB) which represent accumulation of eosinophilic cytoplasmic inclusions in endoplasmic reticulum of mature plasma cells (Mott cells). Most published cases are associated with Helicobacter pylori (H. pylori) infection because of correlation between plasma cell activation and antigenic stimulation. There are insufficient data about H. pylori-negative RBG and very little is known about the natural course of the disease. Case summary A 51-year-old male patient underwent endoscopic screening for mild iron deficiency anemia. Gastroscopy revealed diffuse hyperemia, edema and nodularity of the fundic and corpus mucosa. Due to non-specific endoscopic findings and iron-deficiency anemia our preliminary diagnosis was diffuse type of gastric carcinoma or gastric lymphoma. Biopsy specimens of gastric mucosa showed inflammatory infiltrate rich in Mott cells, consisting entirely of cytoplasmic RB. Absence of nuclear atypia and mitosis of the plasma cells, polyclonal pattern of the Mott cells and negative staining for cytokeratins favored diagnosis of RBG. The patient was treated with proton-pump inhibitor for 8 wk. Long-term clinical and endoscopic surveillance was scheduled. Albeit, there was no improvement in endoscopic features of the gastric mucosa in three consecutive gastroscopies, histopathological findings demonstrated that the chronic inflammatory infiltrate in the fundic mucosa is less pronounced, rich in plasma cells, with almost absent RB and Mott cells. Conclusion The prognosis of this entity is uncertain, that is why these patients are subjects of continuous follow up. |
| Databáze: | OpenAIRE |
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