Inverse relationship of perinatal complications and eye tracking dysfunction in relatives of patients with schizophrenia: evidence for a two-factor model
| Autor: | Sharon J. Tramer, Philip S. Holzman, Dennis K. Kinney, Deborah A. Yurgelun-Todd, Deborah L. Levy |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Pediatrics genetic structures Comorbidity behavioral disciplines and activities Genetic determinism Ocular Motility Disorders Pregnancy Risk Factors mental disorders medicine Humans In patient Family Psychiatry Models Genetic Perinatal complications Models Theoretical medicine.disease Pursuit Smooth Obstetric Labor Complications Psychiatry and Mental health Schizophrenia Etiology Eye tracking Female Birth records Psychology |
| Zdroj: | The American journal of psychiatry. 155(7) |
| ISSN: | 0002-953X |
| Popis: | Because both smooth pursuit eye tracking dysfunction and obstetrical complications are significant risk factors for schizophrenia, the authors tested the predictions of a two-factor model of how eye tracking dysfunction and obstetrical complications covary in patients with schizophrenia, their siblings, and comparison subjects.Psychiatric diagnoses, eye tracking dysfunction, and obstetrical complications noted in birth records were independently assessed in 18 patients with schizophrenia, 16 of their siblings without schizophrenia, and 49 comparison subjects with neither personal nor family histories of schizophrenia.As hypothesized, 1) the combination of eye tracking dysfunction and perinatal obstetrical complications discriminated patients with schizophrenia significantly from subjects without schizophrenia, including siblings of patients with schizophrenia, and 2) eye tracking dysfunction and perinatal obstetrical complications manifested a significant inverse association in the nonschizophrenic siblings of patients with schizophrenia.These results support a two-factor model in which obstetrical complications often interact with genetic liability, indicated by eye tracking dysfunction, to produce schizophrenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|