Frontiers of Ferroptosis in Cancer Treatment

Autor:	Durr-e-shahwar Malik, Mirna Azalea Romero, Saiyada Fatima Maida Halim, Deena Elsori, Lara Youssef, Ishmuratova Margarita Yulaevna, Uteuliyev Yerzhan Sabitaliyevich, Rukset Attar
Rok vydání:	2022
Předmět:	Proteomics Carcinogenesis Iron Neoplasms Ferroptosis Humans General Medicine
Zdroj:	Cellular and Molecular Biology. 68:213-226
ISSN:	1165-158X 0145-5680
DOI:	10.14715/cmb/2022.68.2.31
Popis:	Recent phenomenal advancements in genomic and proteomic technologies and rapid breakthroughs in the interpretation of large gene expression datasets have enabled scientists to comprehensively characterize the gene signatures involved in ferroptosis. Ferroptosis is an iron-dependent form of non-apoptotic cell death that has gained the worthwhile attention of both basic and clinical researchers. Ferroptosis has dichotomous, context-dependent functions both as a tumor suppressor and promoter of carcinogenesis. Essentially, pharmacological modulation of ferroptosis by its induction as well as its inhibition holds enormous potential to overcome drug resistance and to improve the therapeutic potential of chemotherapeutic drugs in a wide variety of cancers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0354f000fdc810795f140f2ccfe975 https://doi.org/10.14715/cmb/2022.68.2.31 Zobrazit plný text záznamu