Sleep-related apneic and apneustic breathing following pneumotaxic lesion and vagotomy
| Autor: | Theodore L. Baker, William C. Dement, Allan Netick |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pulmonary and Respiratory Medicine
Physiology medicine.medical_treatment Rapid eye movement sleep Sleep REM Vagotomy Lesion Electrocardiography Sleep Apnea Syndromes Pons medicine Animals Respiratory system Wakefulness Slow-wave sleep business.industry Electromyography Respiration Apnea Electrooculography Anesthesia Breathing Cats medicine.symptom business psychological phenomena and processes |
| Zdroj: | Respiration physiology. 46(3) |
| ISSN: | 0034-5687 |
| Popis: | Sleep-wakefulness state was found tobe a crucial determinant of respiratory pattern in chronic cats with bilateral lesions of the rostral pontine pneumotaxic complex (PC). Lesions resulted in increased T E , T I , and V T in all sleep and waking states. Several state-specific respiratory effects were also observed: (1) comparatively eupneic breathing during alert wakefulness (W1); (2) greatly increased T E in slow wave sleep (SWS); (3) decreased T E during rapid eye movement sleep (REM), relative to SWS; (4) increased tendency for prolonged T I (brief apneusis) during REM. Bilateral vagotomy at 2–5 weeks after PC lesion exaggerated these effects and caused distinct apneusis during REM. The results confirm that the PC is not essential for the occurence of either rhythmic breathing or for expression of state changes in respiration, although the effects of the PC on breathing in the intact cat may vary as a function of sleep-wakefuleness state. It is suggested that other regulatory systems that influence the central respiratory rhythm generator (RRG) are similarly modulated by state, and that variations in respiratory pattern observed following PC lesion and vagotomy are the result of state-dependent changes in the balance between multiple inputs to the RRG. |
| Databáze: | OpenAIRE |
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