Role of skeletal macrophages in fracture repair: A systematic review
| Autor: | Yanjing Dong, Lih Ying Shin, Zhihao Huang, Oscar K. Lee, Shekhar M. Kumta, Yu Fan Wang, Zihao Wan, Chien Wei Lee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Bone Injury business.industry General Neuroscience Inflammation General Medicine Bone fracture Bone healing Articles medicine.disease Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Intramembranous ossification Medicine General Pharmacology Toxicology and Pharmaceutics Animal testing medicine.symptom Bone regeneration business Endochondral ossification |
| Zdroj: | Biomed Rep |
| ISSN: | 2049-9434 |
| Popis: | In the field of bone research, the importance of the function of skeletal macrophages (sMΦ) and their crucial role in immune homeostasis and bone regeneration has been extensively studied. The aim of the present systematic review was to summarize the role of sMΦ in bone fracture healing and to evaluate their potential for immunoregulatory therapy in bone regeneration. A systematic literature search of PubMed and Embase(®) was performed to retrieve studies on the role of sMΦ in bone injury repair. The Systematic Review Centre for Laboratory animal Experimentation tool was used to assess the risk of bias of the studies included. A total of four articles were included in the present review. A relatively high risk of bias was identified in the included articles as none of the assessors in these studies were blinded. sMΦ were defined by the surface markers F4/80(+), Mac-2(-)(/)(low), TRAP(-), CD169(+), Ly6G(-) and CD115(low). All of the studies provided support for the essential role of sMΦ in intramembranous ossification or endochondral ossification during fracture healing. F4/80(+)Mac-2(-)CD169(+) sMΦ are a promising therapeutic target for immunoregulatory therapy of bone repair due to their essential role in bone formation and homeostasis. Future studies aimed at profiling and modulating sMΦ to promote bone regeneration are required. |
| Databáze: | OpenAIRE |
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