Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray
| Autor: | Beatriz Arauzo, M. Pilar Lobera, Jesus Santamaria, Antonio Monzón |
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| Přispěvatelé: | Instituto de Salud Carlos III, Diputación General de Aragón |
| Rok vydání: | 2021 |
| Předmět: |
Lung Diseases
Electrospray Staphylococcus aureus Polymers and Plastics Microbial Sensitivity Tests medicine.disease_cause Chitosan Alveolar cells chemistry.chemical_compound Ciprofloxacin Administration Inhalation Spectroscopy Fourier Transform Infrared Materials Chemistry medicine Humans Pulmonary administration Particle Size Chromatography Pseudomonas aeruginosa Organic Chemistry Dry powder Antimicrobial Anti-Bacterial Agents medicine.anatomical_structure chemistry A549 Cells Powders medicine.drug |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 ± 248.5 nm and 501.1 ± 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa. Financial support from Nanbiosis platform and Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN). B. Arauzo thanks DGA predoctoral fellowship for personal researcher (2017–2021). Authors thank the “Advanced Microscopy Laboratory” of the “Institute of Nanoscience and Materials of Aragon - University of Zaragoza”, LMA-INMA, for access to their instruments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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