Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice
| Autor: | Yu-Jui Yvonne Wan, Matthew Rolston, Clarissa Santos Rocha, Neal L. Millar, Xuesong Wu, Zhenrui Shi, Samuel T Hwang, Timothy Law, Satya Dandekar, Mindy Huynh, Emma Garcia-Melchor, Kelly N. Haas, Mimi Nguyen, Daisuke Yamada |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.drug_class Antibiotics Reversion Inflammation Dermatology Gut flora Biochemistry Interleukin-23 03 medical and health sciences Psoriatic arthritis Mice 0302 clinical medicine medicine Interleukin 23 Animals Humans Psoriasis Molecular Biology Psoriasiform Dermatitis Imiquimod integumentary system biology business.industry Arthritis Psoriatic Cell Biology medicine.disease biology.organism_classification Gastrointestinal Microbiome Disease Models Animal 030104 developmental biology Diet Western 030220 oncology & carcinogenesis Immunology Dysbiosis medicine.symptom business Signal Transduction |
| Zdroj: | The Journal of investigative dermatology. 141(7) |
| ISSN: | 1523-1747 |
| Popis: | We previously showed that exposure to a high-sugar and moderate-fat diet (i.e., Western diet [WD]) in mice induces appreciable skin inflammation and enhances the susceptibility to imiquimod-induced psoriasiform dermatitis, suggesting that dietary components may render the skin susceptible to psoriatic inflammation. In this study, utilizing an IL-23 minicircle-based model with features of both psoriasiform dermatitis and psoriatic arthritis, we showed that intake of WD for 10 weeks predisposed mice not only to skin but also to joint inflammation. Both WD-induced skin and joint injuries were associated with an expansion of IL-17A‒producing γδ T cells and increased expression of T helper type 17 cytokines. After IL-23 minicircle delivery, WD-fed mice had reduced microbial diversity and pronounced dysbiosis. Treatment with broad-spectrum antibiotics suppressed IL-23‒mediated skin and joint inflammation in the WD-fed mice. Strikingly, reduced skin and joint inflammation with a partial reversion of the gut microbiota were noted when mice switched from a WD to a standard diet after IL-23 minicircle delivery. These findings reveal that a short-term WD intake‒induced dysbiosis is accompanied by enhanced psoriasis-like skin and joint inflammation. Modifications toward a healthier dietary pattern should be considered in patients with psoriatic skin and/or joint disease. |
| Databáze: | OpenAIRE |
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