Hepatic stellate cells: current state and open questions
| Autor: | Hans H. Bock, Claus Kordes, Doreen Reichert, Petra May, Dieter Häussinger |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Clinical Biochemistry Context (language use) Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Hepatic Stellate Cells Humans Reelin Stem Cell Niche Molecular Biology Mesenchymal stem cell Cell Differentiation Stem cell niche Liver regeneration Liver Regeneration Review article 030104 developmental biology Perisinusoidal space Liver 030220 oncology & carcinogenesis Hepatocytes Hepatic stellate cell biology.protein Neuroscience |
| Zdroj: | Biological Chemistry. 402:1021-1032 |
| ISSN: | 1437-4315 1431-6730 |
| DOI: | 10.1515/hsz-2021-0180 |
| Popis: | This review article summarizes 20 years of our research on hepatic stellate cells within the framework of two collaborative research centers CRC575 and CRC974 at the Heinrich Heine University. Over this period, stellate cells were identified for the first time as mesenchymal stem cells of the liver, and important functions of these cells in the context of liver regeneration were discovered. Furthermore, it was determined that the space of Disse – bounded by the sinusoidal endothelium and hepatocytes – functions as a stem cell niche for stellate cells. Essential elements of this niche that control the maintenance of hepatic stellate cells have been identified alongside their impairment with age. This article aims to highlight previous studies on stellate cells and critically examine and identify open questions and future research directions. |
| Databáze: | OpenAIRE |
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