BRCT domains: easy as one, two, three
| Autor: | Glover Jn, Leung Cc |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Genetics
Poly Adenosine Diphosphate Ribose DNA Repair DNA damage DNA repair BRCA1 Protein Extra View Brca1 protein Cell Biology Plasma protein binding Computational biology DNA Biology Protein–protein interaction Protein Structure Tertiary Functional diversity chemistry.chemical_compound BRCT domain chemistry Phosphorylation Tumor Suppressor Protein p53 Molecular Biology Developmental Biology Protein Binding |
| Zdroj: | Cell cycle (Georgetown, Tex.). 10(15) |
| ISSN: | 1551-4005 |
| Popis: | BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage response (DDR). Aside from their established roles as phospho-peptide binding modules, BRCT domains have been implicated in phosphorylation-independent protein interactions, DNA binding and poly(ADP-ribose) (PAR) binding. These numerous functions can be attributed to the diversity in BRCT domain structure and architecture, where domains can exist as isolated single domains or assemble into higher order homo- or hetero- domain complexes. In this review, we incorporate recent structural and biochemical studies to demonstrate how structural features allow single and tandem BRCT domains to attain a high degree of functional diversity. |
| Databáze: | OpenAIRE |
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