Advancing perspectives on prostate cancer: multihormonal influences in pathogenesis
| Autor: | Arthur T. Porter, Crawford Ed, Huhtaniemi I, Garde S, Pontes Je, Ben-Josef E |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Urology Receptor expression Biology Management of prostate cancer Prostate cancer Prostate Internal medicine medicine Vitamin D and neurology Humans Research Prostatic Neoplasms Prostatic Secretory Proteins Luteinizing Hormone medicine.disease Hormones Androgen receptor medicine.anatomical_structure Endocrinology Receptors Androgen Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Endocrine gland Hormone |
| Zdroj: | Molecular urology. 5(4) |
| ISSN: | 1091-5362 |
| Popis: | Nonandrogenic hormones are implicated in the growth and function of the prostate, which is itself an endocrine gland that synthesizes and secretes hormones and growth factors, including follicle-stimulating hormone (FSH) and prostatic inhibin peptide (PIP). Findings of increased FSH concentrations and receptor expression in diseased prostate tissue suggest a role for FSH in prostate cancer growth. Not only does PIP suppress circulating levels of FSH, but it responds to and modulates prostatic FSH, suggesting a close interlinkage of these compounds in controlling both healthy and diseased prostate cells. Other focuses of endocrinologic research include androgen receptors, vitamin D, growth factors (including insulin-like growth factors I and II), and retinoids. Issues such as optimal therapy timing, intermittent administration, and the adoption of a multihormonal approach to the management of prostate cancer remain to be resolved. |
| Databáze: | OpenAIRE |
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