Complex Mammalian-like Hematopoietic System Found in a Colonial Chordate
| Autor: | Gary L. Mantalas, Jonathan M. Tsai, Garry P. Nolan, Tal Raveh, Lucia Manni, Benyamin Rosental, Jennifer Okamoto, Aaron M. Newman, Mark Kowarsky, Katherine J. Ishizuka, Daniel M. Corey, Irving L. Weissman, Rahul Sinha, Shih-Yu Chen, Karla J. Palmeri, Ayelet Voskoboynik, D. Nathaniel Clarke, Stephen R. Quake, Jun Seita, Norma F. Neff |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cytotoxicity Immunologic Male Isoantigens Cellular differentiation Hematopoietic System Chordate Botryllus schlosseri Article 03 medical and health sciences 0302 clinical medicine Immune system Phagocytosis medicine Animals Cell Lineage Myeloid Cells Urochordata Progenitor cell Stem Cell Niche Phylogeny Mammals Immunity Cellular Multidisciplinary biology Cell Differentiation biology.organism_classification Flow Cytometry Hematopoietic Stem Cells Cell biology Hematopoiesis Haematopoiesis 030104 developmental biology medicine.anatomical_structure Female Bone marrow Stem cell Transcriptome 030217 neurology & neurosurgery |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Haematopoiesis is an essential process that evolved in multicellular animals. At the heart of this process are haematopoietic stem cells (HSCs), which are multipotent and self-renewing, and generate the entire repertoire of blood and immune cells throughout an animal's life1. Although there have been comprehensive studies on self-renewal, differentiation, physiological regulation and niche occupation in vertebrate HSCs, relatively little is known about the evolutionary origin and niches of these cells. Here we describe the haematopoietic system of Botryllus schlosseri, a colonial tunicate that has a vasculature and circulating blood cells, and interesting stem-cell biology and immunity characteristics2-8. Self-recognition between genetically compatible B. schlosseri colonies leads to the formation of natural parabionts with shared circulation, whereas incompatible colonies reject each other3,4,7. Using flow cytometry, whole-transcriptome sequencing of defined cell populations and diverse functional assays, we identify HSCs, progenitors, immune effector cells and an HSC niche, and demonstrate that self-recognition inhibits allospecific cytotoxic reactions. Our results show that HSC and myeloid lineage immune cells emerged in a common ancestor of tunicates and vertebrates, and also suggest that haematopoietic bone marrow and the B. schlosseri endostyle niche evolved from a common origin. |
| Databáze: | OpenAIRE |
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