Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy

Autor:	Rosalio Ramos Payan, Maricela García‑Lechuga, Mary Fafutis Morris, Thalía Gabriela Pérez‑Suárez, Marcela Torres‑Hernández, Julio Granados, Nora Magdalena Torres‑Carrillo, Rosario Rodríguez‑Guillén, Iris Estrada Garcia, Roberto Arenas Guzmán, Sergio Estrada Parra, Mónica Escamilla‑Tilch
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Population General Biochemistry Genetics and Molecular Biology PTPN22 03 medical and health sciences 0302 clinical medicine Genotype medicine SNP General Pharmacology Toxicology and Pharmaceutics Allele education Mycobacterium leprae Genotyping education.field_of_study biology General Neuroscience General Medicine Articles biology.organism_classification medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Immunology Mexican mestizo protein tyrosine phosphatase non-receptor type 22 gene Leprosy leprosy
Zdroj:	Biomedical Reports
ISSN:	2049-9442 2049-9434
Popis:	Leprosy, a human chronic granulomatous disease caused by Mycobacterium leprae (M. leprae), remains endemic in certain countries despite the use of multidrug therapy. Recently, several host genes modulating the immune responses to M. leprae infection have been suggested to influence the acquisition and clinical course of leprosy. Lymphoid protein tyrosine phosphatase, encoded by the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, serves a negative regulatory role in T cell activation. The non-synonymous single-nucleotide polymorphism (SNP) rs2476601 (1858C>T) has been associated with autoimmune diseases. Here, the present study investigated if rs2476601 polymorphism was associated with leprosy in a Mexican mestizo population. Genotyping was performed in patients with leprosy (n=189) and control subjects (n=231) from regions with higher incidence of leprosy. Genotypic (P=0.44) and allelic frequencies (P=0.45) of the rs2476601 polymorphism were similar between patients and controls; genotypic frequencies were 91 vs. 94% for CC and 9 vs. 6% for CT, and the TT genotype was absent in both groups. Allelic frequencies were 96 vs. 97% for C, and 4 vs. 3% for T. In the same way, the genotypic (P=0.46) and allelic frequencies (P=0.47) from MB patients and controls were similar. In conclusion, there was a lack of association of the PTPN22 rs2476601 polymorphism with the development of leprosy, which suggests that this SNP was not a genetic risk factor for leprosy in the Mexican mestizo population studied.
Databáze:	OpenAIRE
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