Naloxone effect on ANP in trained and untrained rats
| Autor: | Gutkowska J, Gharib C, J. Fareh, Allevard Am, J. Ibanez-Santos, D. Desplanches, Gauquelin G |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Immunology (+)-Naloxone Atrial natriuretic peptide Internal medicine Physical Conditioning Animal Medicine Animals Opioid peptide Receptor Pharmacology business.industry Naloxone Muscles Rats Inbred Strains Peripheral Rats Oxygen Endocrinology Hypothalamus cardiovascular system Endorphins business hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor circulatory and respiratory physiology |
| Zdroj: | Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 100(3) |
| ISSN: | 0742-8413 |
| Popis: | 1. The effect of a dose of naloxone (1 mg·kg −1 b.w.) on peripheral (plasma, atria) and central (hypothalamus, hypophysis) levels of atrial natriuretic peptide (ANP) was investigated in the rat. 2. In control rats, an acute subcutaneous dose of naloxone produced no significant change in plasma ANP, but a decrease (NS) in atrial ANP concentration. 3. In physically conditioned animals, naloxone produced a significant decrease in atrial ANP levels. Receptor sensitivity may thus be involved in this differential response. 4. In hypothalamus and hypophysis, no effect on ANP concentrations was seen after a high dose of naloxone whether in control or in physically conditioned animals, suggesting peripheral and central ANP might be differently regulated, at least after chronic endurance physical training. |
| Databáze: | OpenAIRE |
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