MR signal change in venous thrombus relates organizing process and thrombolytic response in rabbit
| Autor: | Hiroshi Sugimura, Taketoshi Asanuma, Keiichi Kawai, Misaki Takahashi, Tosiaki Miyati, Atsushi Yamashita, Yasuyoshi Kuroiwa, Yujiro Asada, Eiji Furukoji, Toshiya Azuma, Shozo Tamura |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Platelets
Male Pathology medicine.medical_specialty Erythrocytes Magnetic Resonance Spectroscopy Time Factors medicine.medical_treatment Biomedical Engineering Biophysics Tissue plasminogen activator Fibrin Imaging Three-Dimensional Jugular vein medicine Animals Humans Radiology Nuclear Medicine and imaging Platelet cardiovascular diseases Thrombus Venous Thrombosis biology medicine.diagnostic_test business.industry Signal Processing Computer-Assisted Thrombosis Magnetic resonance imaging Thrombolysis medicine.disease Magnetic Resonance Imaging Venous thrombosis Tissue Plasminogen Activator cardiovascular system biology.protein Rabbits Jugular Veins business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Magnetic Resonance Imaging. 29:975-984 |
| ISSN: | 0730-725X |
| Popis: | Venous thrombus is subsequently organized and replaced by fibrous connective tissue. However, the sequential changes in venous thrombi are not reliably detected by current noninvasive diagnostic techniques. The purpose of this study is to reveal whether magnetic resonance (MR) can detect venous thrombus, define thrombus age and predict thrombolytic responses. Thrombus in the rabbit jugular vein was imaged with a 1.5-T MR system at 4 h and at 1, 2 and 4 weeks using three-dimensional (3D) fast asymmetric spin echo T2-weighted (T2W) and 3D-gradient echo T1-weighted (T1W) sequences. The jugular veins were histologically assessed at each time point. Magnetic resonance imaging (MRI) was also performed in vivo before and 30 min after tissue plasminogen activator (t-PA) administration. The thrombi in MRI were comparable in size to histological sections. The signal intensity (SI) of thrombi at 4 h was heterogeneously high or low on T2W or T1W images, respectively. The SI of thrombi on T2W images decreased time-dependently, but increased on T1W images at 1 and 2 weeks. Morphological analysis showed time-dependent decreases in erythrocyte, platelet and fibrin areas and time-dependent increases in smooth muscle cell, macrophage, collagen and iron areas. The t-PA administration significantly decreased thrombus volume at 4 h but not at 1, 2 and 4 weeks. Venous thrombosis can be reliably and noninvasively detected by MRI. Measurement of SI might support assessments of thrombus age and thrombolytic response. |
| Databáze: | OpenAIRE |
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