Extract of Aquilaria crassna leaves and mangiferin are vasodilators while showing no cytotoxicity
Autor: | Kornkanok Ingkaninan, Tamkeen Urooj Paracha, Natakorn Kamkaew, Usana Chatturong, Eakkaluk Wongwad, Sutthinee Wisutthathum, Anjaree Inchan, Krongkarn Chootip |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Aorta
Vascular smooth muscle biology Chemistry lcsh:R lcsh:Medicine Vasodilation Pharmacology Aquilaria crassna biology.organism_classification chemistry.chemical_compound medicine.anatomical_structure Complementary and alternative medicine medicine.artery medicine Aquilaria Mangiferin Mesenteric arteries Artery |
Zdroj: | Journal of Traditional and Complementary Medicine, Vol 9, Iss 4, Pp 237-242 (2019) |
ISSN: | 2225-4110 |
Popis: | The leaves of Aquilaria spp. promote “physiological balance”, and are “cardiotonic and provide blood nourishment”. In Asia, these leaves are increasingly consumed as tea and claimed to provide benefits to cardiovascular function, albeit without any scientific proof. Therefore, this study sought to evaluate the action of Aquilaria crassna leaf aqueous extract (AE) on vascular function and vascular smooth muscle cytotoxicity. AE and a main constituent, mangiferin were investigated for their vasorelaxation of rat mesenteric arteries and aortae in vitro. Acute cytotoxicity of AE (0.1–1000 μg/ml) and mangiferin (0.1–100 μM) on rat enzymatically isolated vascular smooth muscle cells was assayed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. AE dilated rat mesenteric arteries (EC50∼107 μg/ml, Emax∼95%) more than aorta (EC50∼265 μg/ml, Emax∼76%, p |
Databáze: | OpenAIRE |
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