Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms
| Autor: | Songfeng Hu, Hongting Jin, Di Chen, Peijian Tong, Jushi Zhang, Bingjiang Xia |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Cartilage Bone matrix Osteoarthritis Bioinformatics medicine.disease Article Impaired mobility Pathogenesis Joint disease Endocrinology medicine.anatomical_structure Physical therapy medicine Molecular targets Animals Humans Orthopedics and Sports Medicine Total joint replacement business Aged |
| Zdroj: | Calcified Tissue International. 95:495-505 |
| ISSN: | 1432-0827 0171-967X |
| Popis: | Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage matrix and development of OA are poorly understood and there are currently no effective interventions to decelerate the progression of OA or retard the irreversible degradation of cartilage except for total joint replacement surgery. In this paper, the important molecular mechanisms related to OA pathogenesis will be summarized and new insights into potential molecular targets for the prevention and treatment of OA will be provided. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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