Multiple pesticides in mothers' hair samples and children's measurements at birth: Results from the French national birth cohort (ELFE)

Autor: Cécile Zaros, Brice M.R. Appenzeller, Emilie M. Hardy, Cécile Chevrier, Rémi Béranger, Marie-Aline Charles, Anne-Claire Binter
Přispěvatelé: Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Luxembourg Institute of Health (LIH), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), EFS-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), R15158NN, Fondation de France, Fondation Mustela, PNR EST-13-138, French Agency for Food, Environmental and Occupational Health & Safety, French Agency for Biodiversity, ANR-11-EQPX-0038, Investissements d'avenir' program, ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Birth weight
Population
010501 environmental sciences
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Environmental health
Epidemiology
medicine
Humans
030212 general & internal medicine
Pesticides
Child
education
0105 earth and related environmental sciences
2. Zero hunger
education.field_of_study
business.industry
Confounding
Infant
Newborn
Public Health
Environmental and Occupational Health
Maternal exposures
Environmental exposure
Fetal development
Propoxur
Pesticide
3. Good health
[SDV] Life Sciences [q-bio]
TCPy
chemistry
Maternal Exposure
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Environmental Pollutants
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
France
business
Hair
Zdroj: International Journal of Hygiene and Environmental Health
International Journal of Hygiene and Environmental Health, Elsevier, 2020, 223 (1), pp.22-33. ⟨10.1016/j.ijheh.2019.10.010⟩
International Journal of Hygiene and Environmental Health, 2020, 223 (1), pp.22-33. ⟨10.1016/j.ijheh.2019.10.010⟩
ISSN: 1438-4639
DOI: 10.1016/j.ijheh.2019.10.010
Popis: International audience; Background - A growing body of studies now suggests that the general population is continuously and ubiquitously exposed to numerous pesticides. However, studies investigating the possible role of environmental exposure to pesticides on fetal growth have focused on a limited set of substances, despite the hundreds of modern pesticides currently available. Aim - To explore the relation between maternal hair concentrations of 64 pesticides and metabolites and their newborns' measurements at birth, with data from the ELFE French nationwide birth cohort. Methods - We measured 64 compounds (10-100% detection) in bundles of hair 9 cm long collected at birth from 311 women who gave birth in France in 2011. We assessed their associations with birth weight, length, and head circumference, adjusted for potential confounders, and used elastic net regularization to simultaneously select the strongest predictors of measurements at birth. Selected variables were multiply imputed for missing values, and unpenalized estimators were assessed by standard linear regression. Results - We observed statistically significant associations between maternal hair concentrations of seven pesticides or pesticide metabolites and birth measurements (weight: fipronil sulfone; length: TCPy, bitertanol, DEP, and isoproturon; head circumference: tebuconazole and prochloraz). Analyses restricted to boys identified 12 additional compounds: 8 independently associated with birth weight (3Me4NP, DCPMU, DMST, fipronil, mecoprop, propoxur, fenhexamid, and thiabendazole), 2 with birth length (dieldrin and β-endosulfan), and 6 with head circumference (β-endosulfan, β-HCH, fenuron, DCPMU, propoxur, and thiabendazole). Conclusion - Our results suggest that prenatal exposure to 19 pesticides or metabolites from various chemical families may influence measurements at birth. As with any exploratory research findings, results should be interpreted cautiously, until they are replicated or verified by further epidemiological or mechanistic studies.
Databáze: OpenAIRE
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