| Autor: |
Nils Cordes, Leoni A. Kunz-Schughart, Daniel Zips, Claudia Förster, Lydia Schneider, Iris Eke |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22397511.v1 |
| Popis: |
PDF file - 621K, Supplementary Figure S1. Treatment with Cetuximab inhibits EGF-mediated EGFR phosphorylation under 2D and 3D cell culture conditions in a cell line-dependent manner. Supplementary Figure S2. Induction of Cetuximab-mediated apoptosis in non-irradiated and irradiated 3D grown SCC cells. Supplementary Figure S3. EGFR inhibition with Cetuximab results in minor Caspase 3 cleavage. Supplementary Figure S4. Treatment with Cetuximab modulates tyrosine and serine protein phosphorylation. Supplementary Figure S5. JNK inhibition using siRNA or pharmacological inhibitor (SP600125) reduces cell survival of SCC cells. Supplementary Figure S6. JNK inhibition impairs Cetuximab-mediated c-Jun S63 phosphorylation. Supplementary Figure S7. JNK2 knockdown sensitizes UTSCC5 cells to Cetuximab-mediated radiosensitization. Supplementary Figure S8. EGFR and JIP-4 co-precipitate in untreated FaDu 3D cell cultures |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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