Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers
| Autor: | Edyta Katarzyna Głażewska, Joanna Osada, Milena Dąbrowska, Monika Zajkowska, Lech Chrostek, Ewa Gacuta, Sławomir Ławicki, Maciej Szmitkowski, Grażyna Ewa Będkowska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology Disease Matrix metalloproteinase Carcinoma Ovarian Epithelial Pathogenesis Ovarian tumor 0302 clinical medicine Neoplasms Glandular and Epithelial Aged 80 and over Ovarian Neoplasms Metalloproteinase Obstetrics and Gynecology Middle Aged Oncology 030220 oncology & carcinogenesis Matrix Metalloproteinase 7 Tumor markers Female Menopause MMP-7 medicine.medical_specialty HE4 Sensitivity and Specificity lcsh:Gynecology and obstetrics Diagnosis Differential 03 medical and health sciences CA125 WAP Four-Disulfide Core Domain Protein 2 TIMP-1 medicine Humans lcsh:RG1-991 Tumor marker Aged Neoplasm Staging Tissue Inhibitor of Metalloproteinase-1 business.industry Research Cancer Proteins Epithelial ovarian cancer medicine.disease 030104 developmental biology ROC Curve CA-125 Antigen Case-Control Studies Neoplasm Grading business Ovarian cancer Biomarkers |
| Zdroj: | Journal of Ovarian Research, Vol 10, Iss 1, Pp 1-10 (2017) Journal of Ovarian Research |
| ISSN: | 1757-2215 |
| Popis: | Background MMP-7 and TIMP-1 may play a role in the pathogenesis of cancer disease. In this study we investigated plasma levels of selected metalloproteinase and its tissue inhibitor in comparison to plasma levels of the commonly accepted tumor markers (CA 125 and HE4) in selected histological types of epithelial ovarian cancer patients as compared to control groups: patients with a benign ovarian tumor and healthy subjects. Plasma levels of MMP-7 and TIMP-1 were determined using ELISA, CA 125 and HE4 – by CMIA methods. Results Plasma levels of all biomarkers studied were significantly higher in ovarian cancer patients as compared to both control groups. MMP-7 demonstrated comparable to HE4 or CA125 values of diagnostic sensitivity (SE: 61%; 68%; 58%, respectively), specificity (SP: 95%; 95%; 98%, respectively), positive (PPV: 93%; 96%; 98%, respectively) and negative predictive values (NPV: 61%; 66%; 60%, respectively) in the groups tested. The combined use of the aforementioned biomarkers resulted in a further increase in diagnostic criteria and AUC, especially in the early stages of the disease. Conclusions These findings suggest the usefulness of combining MMP-7 with CA 125 and HE4 in the diagnosis of epithelial ovarian cancer as a new tumor marker panel. Electronic supplementary material The online version of this article (doi:10.1186/s13048-017-0338-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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