Remarkable lack of biological activity exhibited by a dna-reactive and water-soluble cis-bis(phosphino) platinum(II) complex

Autor:	Guendalina Trovóa, Andrea Tapparo, Franco Bordin, Bruno Longato, A. Furlani, Manlio Palumbo, Francarosa Baccichetti, Vito Scarcia, Benedetto Corain
Rok vydání:	1993
Předmět:	chemistry.chemical_compound Aqueous solution chemistry Dimethyl sulfoxide Stereochemistry chemistry.chemical_element Sulfoxide Biological activity General Chemistry Nuclear magnetic resonance spectroscopy Platinum DNA Nucleobase
Zdroj:	J. Chem. Soc., Dalton Trans.. :1547-1550
ISSN:	1364-5447 0300-9246
DOI:	10.1039/dt9930001547
Popis:	The solvolytic behaviour of the complex cis-[Pt(PMe3)2Cl2] was investigated in water and dimethyl sulfoxide. Mono-and bis-solvento species have been characterized mainly by 31P NMR spectroscopy. The water-soluble species cis-[{Pt(PMe3)2(µ-OH)}2]2+, thermodynamically stable at physiological pH values and known to be reactive with pyrimidinic nucleobases, is found to be also quite reactive with purified single- and double-strand DNA, as shown by 31P NMR spectroscopy. However, the same hydroxo complex is found to be remarkably inactive towards Eagle's KB cell line and Ehrlich's ascitic tumour cells. This lack of biological activity is maintained also when the complex is administered to Eagle's KB cell line as a suspension of L-α-dipalmitoylphosphatidylcholine liposomes.
Databáze:	OpenAIRE
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