Effect of prior nicotine treatment on drug induced changes in serum LH concentrations in rats
Autor: | M. C. Davis, Charles A. Hodson, Hubert W. Burden |
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Rok vydání: | 1997 |
Předmět: |
Male
Nicotine medicine.medical_specialty medicine.drug_class Narcotic Antagonists (+)-Naloxone Clonidine Drug Administration Schedule General Biochemistry Genetics and Molecular Biology Naltrexone Gonadotropin-Releasing Hormone Rats Sprague-Dawley Internal medicine medicine Haloperidol Animals Drug Interactions Nicotinic Agonists General Pharmacology Toxicology and Pharmaceutics Opioidergic Neurotransmitter Agents Naloxone Chemistry General Medicine Luteinizing Hormone Stimulation Chemical Rats Endocrinology Dopamine Antagonists Luteinizing hormone Adrenergic alpha-Agonists Opioid antagonist medicine.drug |
Zdroj: | Life Sciences. 60:2303-2308 |
ISSN: | 0024-3205 |
DOI: | 10.1016/s0024-3205(97)00285-3 |
Popis: | The effect of daily injections of nicotine on drug induced changes in LH secretion was investigated in male rats. Daily administration of nicotine for 7 days resulted in decreased basal serum LH concentrations. Nicotine treatment blocked naloxone induced LH release and reduced LHRH induced increases in serum LH. Clonidine induced increases in serum LH were not altered by nicotine treatment and haloperidol treatment did not alter nicotine induced decreases in serum LH. In an acute study nicotine blocked LH secretion induced by the long acting opioid antagonist naltrexone. Collectively these results indicate that opioidergic neurons are involved in the reduction in serum LH that occurs following nicotine. They also indicate that chronic nicotine treatment can reduce the pituitary gland response to LHRH. |
Databáze: | OpenAIRE |
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