Enlightening the advancements in electrochemical bioanalysis for the diagnosis of Alzheimer’s disease and other neurodegenerative disorders
| Autor: | Ana Montero-Calle, José M. Pingarrón, Rodrigo Barderas, Verónica Serafín, Susana Campuzano, Claudia A. Razzino, P. Yáñez-Sedeño, María Pedrero, Maria Gamella |
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| Rok vydání: | 2020 |
| Předmět: |
Proteomics
Bioanalysis Clinical Biochemistry Population Pharmaceutical Science Biosensing Techniques Disease Computational biology 01 natural sciences Analytical Chemistry Alzheimer Disease Drug Discovery medicine Humans Electrochemical biosensor education Spectroscopy Immunoassay education.field_of_study Amyloid beta-Peptides 010405 organic chemistry Chemistry 010401 analytical chemistry Neurodegenerative Diseases medicine.disease Peptide Fragments 0104 chemical sciences Review article Alzheimer's disease Signal amplification Biomarkers Healthcare system |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 189:113437 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2020.113437 |
| Popis: | Neurodegenerative disorders (NDD), and particularly Alzheimer's disease (AD), are one of the greatest challenges facing our current medicine and society because of its increasing incidence and the high burden imposed both on patients' families and health systems. Despite this, their accurate diagnosis, mostly conducted by cerebrospinal fluid (CSF) analysis or neuroimaging techniques, costly, time-consuming, and unaffordable for most of the population, remains a complex task. In this situation, electrochemical biosensors are flourishing as promising alternative tools for the simple, fast, and low-cost diagnosis of NDD/AD. This review article provides the relevant clinical details of NDD/AD along with the closely related genetic (genetic mutations, polymorphisms of ApoE and specific miRNAs) and proteomic (amyloid-β peptides, total and phosphorylated tau protein) biomarkers circulating mostly in CSF. In addition, the article systematically enlightens a general view of the electrochemical affinity biosensors (mostly aptasensors and immunosensors) reported in the past two years for the determination of such biomarkers. The different developed strategies, analytical performances and applications are comprehensively discussed. Recent advancements in signal amplification methodologies involving smart designs and the use of nanomaterials and rational surface chemistries, as well as the challenges that must be struggled and the prospects in electrochemical affinity biosensing to bring more accessibility to NDD/AD diagnosis, prognosis, and follow-up, are also pointed out. |
| Databáze: | OpenAIRE |
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