Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model : a central role for gene environment interactions
| Autor: | David M. Thomson, Greg Bristow, Emma J. Mitchell, Rebecca L. Openshaw, Neil Dawson, Brian J. Morris, Judith A. Pratt |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Drug Agonist Genetics of the nervous system RM medicine.drug_class media_common.quotation_subject Social Interaction lcsh:Medicine Anxiety Motor Activity Biology Pharmacology Anxiolytic Article Behavioural methods 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Autistic Disorder Eletriptan Social Behavior lcsh:Science Receptor Gene media_common Multidisciplinary lcsh:R medicine.disease Chromosomes Mammalian Phenotype Acetylcysteine Mice Inbred C57BL Disease Models Animal 030104 developmental biology Social behaviour Autism Gene-Environment Interaction lcsh:Q Chromosome Deletion 030217 neurology & neurosurgery Neuroscience medicine.drug |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | There are no current treatments for autism, despite its high prevalence. Deletions of chromosome 16p11.2 dramatically increase risk for autism, suggesting that mice with an equivalent genetic rearrangement may offer a valuable model for the testing of novel classes of therapeutic drug. 16p11.2 deletion (16p11.2 DEL) mice and wild-type controls were assessed using an ethological approach, with 24 h monitoring of activity and social interaction of groups of mice in a home-cage environment. The ability of the excitation/inhibition modulator N-acetyl cysteine (NAC) and the 5-HT1B/1D/1F receptor agonist eletriptan to normalise the behavioural deficits observed was tested. 16p11.2 DEL mice exhibited largely normal behaviours, but, following the stress of an injection, showed hyperlocomotion, reduced sociability, and a strong anxiolytic phenotype. The hyperactivity and reduced sociability, but not the suppressed anxiety, were effectively attenuated by both NAC and eletriptan. The data suggest that 16p11.2 DEL mice show an autism-relevant phenotype that becomes overt after an acute stressor, emphasising the importance of gene-environmental interactions in phenotypic analysis. Further, they add to an emerging view that NAC, or 5-HT1B/1D/1F receptor agonist treatment, may be a promising strategy for further investigation as a future treatment. |
| Databáze: | OpenAIRE |
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